nuclear hormone receptors การใช้

• The AR is a nuclear hormone receptor transcription factor that contains polyglutamine repeats.
• The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine.
• This protein is a member of nuclear hormone receptor family of steroid hormone receptors.
• These proteins belong to the nuclear hormone receptor class of transcription factors that regulate gene transcription.
• The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors.
• It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus.
• Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors.
• Similarly, another nuclear hormone receptor co-repressor, SMRT, has demonstrated an opposing effect in genetically engineered mice.
• When forming a complex with androgen receptor ( and possibly other nuclear hormone receptors ), LSD1 changes its substrates to H3K9me2.
• The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions.
• This gene encodes a protein with sequence similarity to the estrogen receptor, a member of nuclear hormone receptor family of steroid hormone receptors.
• These nuclear hormone receptor proteins are the insect orthologs of the mammalian farnesoid X receptor ( FXR ) and retinoid X receptor ( RXR ) proteins, respectively.
• Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps : competition with coactivators and the direct effects of its transcriptional repressor function.
• The major group of regulators that is targeted is a group of nuclear hormone receptors known as peroxisome proliferator activated receptors ( PPAR?, ?, and ? ).
• This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein.
• Jensen
  鹯st described the estrogen receptor in 1958 and subsequently discovered the superfamily of nuclear hormone receptors along with a unifying mechanism that regulates embryonic development and diverse metabolic pathways.
• Downstream targets of this nuclear hormone receptor are involved principally in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer.
• The three men, starting with Jensen in the 1950s and continuing with Chambon and Evans in the 1980s, opened up the field of studying proteins called nuclear hormone receptors, the foundation said.
• These studies suggest that new drugs targeting the molecular interaction between nuclear hormone receptors and their regulatory cofactors could provide a useful new category of therapeutic targets to be developed in an effort to control obesity.
• Dr . Russell Nofsinger and Dr . Ronald Evans of the Salk Institute showed that disruption of the molecular interaction between SMRT and their nuclear hormone receptor partners leads to increased adiposity and a decreased metabolic rate.